99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!

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99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!
99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!

99% High Purity and Top Quality Letrozole 112809-51-5 with reasonable price on Hot Selling!!

  • Item No.TOP
    MOQ1 Kilogram
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From $859.30859.20 / Kilogram
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Quick Details
Product name Letrozole
Appearance White powder
Place of Origin CN;SHN
Usage Animal Pharmaceuticals
Brand Name xigema
certificateISO
Model Number TOP
Application Pharmaceutical Raw Intermediates
CAS112809-51-5
ColorWhite
NameLetrozole
Assay99.0%-101%
Shelf Life 2 years
Grade Standard Medicine Grade
Type Antineoplastic Agents
CAS No. 112809-51-5
Other Names Letrozole
MFC17H11N5
EINECS No. N/A
Purity99%min
Grade Phamaceutical Grade

Packaging & Delivery

Selling Units:
Kilogram

 

Specifications

Letrozole 112809-51-5 
1.CAS NO:112809-51-5 
2.Quality: USP32 
3.Documents: GMP 
4.Use:antineoplastic agent

Description

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Product Name:

Letrozole

Synonyms:

4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara

CAS:

112809-51-5

MF:

C17H11N5

MW:

285.3

EINECS:

 

Product Categories:

Anti-Cancer;Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Letrozole;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;APIs;Antibiotics;Aromatics;Heterocycles;ELOXATIN;Anti-cancer&immunity

Mol File:

112809-51-5.mol

 

Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery. letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome p450 unit, the action is specific,and letrozol does not reduce production of mineralo-or corticosteroids.

 

 Letrozole is a new generation aromatase inhibitor, is a synthetic derivative of benzyl triazole, letrozole by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. Chemotherapy and radiotherapy for breast cancer.

 

 

Functions

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Letrozole is a new generation of highly selective aromatase inhibitors for synthetic benzyl triazole derivatives, by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. In vivo activity than the first-generation aromatase inhibitor aminoglutethimide 150-250 times stronger. Due to its high selectivity, without affecting glucocorticoid mineralocorticoid and thyroid function, high doses of a corticosteroid like substances secreted without inhibition, and therefore it has a high therapeutic index. The pre-clinical studies have shown that letrozole for the whole body system and there is no potential target organ toxicity, no mutagenic and carcinogenic effects, and less side effects, well tolerated, and other aromatase inhibitors and anti- estrogen drugs compared to stronger anti-tumor effect. Suitable for patients with early breast cancer treatment as well as anti-estrogen therapy after treatment of advanced breast cancer in postmenopausal invalid.
December 2005 the British Medicines and Healthcare products regulatory approvals Novartis produced letrozole (Femara) is used to treat breast cancer patients, allowing it to be used after surgery, postmenopausal hormone-positive early invasive breast cancer patients. This is the second in June 2005 approved the British AstraZeneca Arimidex approved the first two aromatase inhibitors. Two drugs in clinical trials have shown that, compared with the current standard tamoxifen treatment can better prevent the risk of breast cancer recurrence.

Letrozole and anastrozole tablets distinguish letrozole tablets: for postmenopausal women with advanced breast cancer, second-line therapy for the treatment of multiple anti-estrogen therapy after failure.

Anastrozole: selective triazole aromatase inhibitors a potent, can inhibit the cytochrome P-450 aromatase enzyme depends thus blocking the biosynthesis of estrogens, and estrogen to stimulate breast cancer cells The main factor in the growth. The product of human placental aromatase 50% inhibitory concentration (IC50) is 15nmol / L.

 

Analysis

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Tests

Specifications

Results

Appearance

White or off-white crystaline powder

White

Crystalline powder

Solubility

 

Soluble in Chloroform;

Soluble in ethanol when heated

Conform

ldentification

(1)Maximum absorption in wavelength of 240 nm

Minimum absorption in wavelength of 215 nm

Conform

Conform

(2)Infrared spectrum should be in accordance the dominant peak of contrast

In accordance with the dominant peak of contrast

Melting points

182°C-184°C

182°C

Related substances

≤0.5%

0.3%

Single impurity

≤0.3%

0.2%

Loss on drying

≤1.0%

0.8%

[Assay]C17H11N5

(On anhydrous basis)

≥98.0%

99.2%

Conclusion

Conforms Specifications of Enterprise Standard.

 

 

Packaging & Shipping

 

 

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Our Services

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Company Information

 

Qingdao xigema Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals 

and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".xigema has 21 subsidiaries and holding companies.

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FAQ

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Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.

Q2: How to contact with us?
Click the Alibaba"Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.

Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account

Q4:Can you give me a discount price?
Surely,It depend on your qty

Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

If you are interested,welcome to contact with us.
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