Factory supplt High purity Doxorubicin Adriamycin/Doxorubicin hydrochloride,CAS 25316-40-9
1-9 Kilogram
$64,350.00
≥ 10 Kilogram
$64,349.90
- Item No. High PurityMOQ 1 Kilogram
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High Purity Doxorubicin hydrochloride
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Product profile
CAS No: | 25316-40-9 |
---|---|
AHFS Codes: | 10:00.0 |
Synonyms: | (8S,10S)-10-((3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride |
ATC code: | L01DB01 |
Molecular Weight: | 579.983 g/mol |
PubChem: | 31703 |
Chemical Formula: | C27-H29-N-O11.Cl-H |
DrugBank: | DB00997 |
Assay/Purity: | Typically NLT 98% |
IUPAC Name: | (8S,10S)-10-(4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione |
SMILES: | C[C,H]1[C,H]([C,H](C[C,,H](O1)O[C,H]2C[C,,](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O.Cl |
InChl: | 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1 |
Real Shot
Product of Description
Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9. Orange-Red Crystalline Solid.Used as an antineoplastic.Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA.
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.Antibacterial;DNA intercalant.Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Function
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.
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