Caffeic acid phenethyl ester referred CPAE, is one of the main active component of propolis, the effectiveness of the herpes virus, other viruses were inhibited by propolis components as well as adenovirus, influenza virus. Propolis CAPE, quercetin, isoprene, esters, isorhamnetin, Kora prime and glycosides, polysaccharides and other substances have anticancer activity, can inhibit the proliferation of tumor cells, cancer cells have a certain toxic effect and CAPE tumor cells with specific lethality. Jeng and so that CAPE involved in natural cell death induction, while malignant lesions have a cytotoxic effect, CAPE concentration in a very small amount of tumor can be improved by a factor (12-0- tetradecanoyl whisk wave-13-acetate ester) induced inflammation. Caffeic acid phenethyl ester structure comprises from zero to two hydroxy (catechol) phenyl structure, a common structure for the removal of free radicals, and there are two ortho phenolic hydroxyl group on the benzene ring of the high electron density, extreme Easy auto-oxidation and coloration Bors reported, 0 dihydroxybenzene ring structure of flavonoids play a role in anti-oxidation plays an important role. Chemical composition of propolis is different in different regions, thus CAPE content is different, studies have shown that propolis produced in China in CAPE content is relatively high, reaching l5 ~ 25mg /g, and propolis produced in Brazil does not contain CAPE. Lab caffeic acid and β- bromo-ethylbenzene as raw material, potassium phosphate as catalyst caffeic acid phenethyl ester, yield of 60%.
Functions of Phenethyl caffeate:
1. Caffeic acid phenethyl ester has been shown to inhibit carcinogenesis, although other experiments show possible carcinogenic effects. It is also known as an antioxidant in vitro and also in vivo. 2. Caffeic acid phenethyl ester also shows immunomodulatory and anti-inflammatory activity. 3. Caffeic acid phenethyl ester outperformed the other antioxidants, reducing aflatoxin production by more than 95 percent. The studies are the first to show that oxidative stress that would otherwise trigger or enhance.Aspergillus flavus aflatoxin production can be stymied by caffeic acid. This opens the door to using natural anti-fungicide methods by supplementing trees with antioxidants.