Nintedanib is the first approved drug for the management of idiopathic pulmonary fibrosis (IPF), a rare but often fatal lung disease. Nintedanib is believed to exert its mechanism of action by inhibiting multiple receptor tyrosine kinases, including those that have been implicated in the pathogenesis of IPF (i.e., fibroblast growth factor receptor, platelet-derived growth factor receptor, and vascular endothelial growth factor receptor). Nintedanib also inhibits nonreceptor tyrosine kinases, although the contribution of this inhibition in the efficacy of the drug is unknown.

Qingdao Sigma Chemical Co., Ltd.is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.