N-Caffeoyldopamine is a phytochemical found in various plants, including cocoa (Theobroma cacao L.). N-caffeoyldopamine and its natural analogs (N-cinnamoyldopamine, N-coumaroyldopamine, N-feruloyldopamine, and N-sinapoyldopamine) were synthesized and investigated to determine their potency as P-adrenoceptor agonists, because they have chemical structural moieties found in P-adrenoceptor agonists. Among the compounds tested in this study, N-coumaroyldopamine and N-caffeoyldopamine were the two most potent compounds, able to increase cAMP at the concentrations <0.05 &mu; M in U937 cells. The decreasing order of potency was N-coumaroyldopamine > N-caffeoyldopamine > N-feruloyldopamine > N-sinapoyldopamine > N-cinnamoyldopamine. Using &beta; 2-specific antagonists (butoxamine and ICI 118551), N-coumaroyldopamine and N-caffeoyldopamine were found to increase cAMP via &beta; 2-adrenoceptors in U937 cells. In producing cAMP in U937 cells, N-coumaroyldopamine and N-caffeoyldopamine were as potent as several well-known &beta; 2-adrenoceptor agonists (salbutamol, procaterol, and fenoterol). These results indicate that N-coumaroyldopamine and N-caffeoyldopamine are potent compounds able to increase cAMP via &beta; 2-adrenoceptors in U937 cells.

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Function&Application

To enhance cAMP levels via beta 2 adrenoceptors. It also causes significant increments in the levels of mTOR that become activated within the body. This is a type of protein enzyme that regulates and maintains growth, protein synthesis and overall muscular hypertrophy.

This ingredient also activates much more mTOR within the body. mTOR is a certain type of protein kinase that is responsible for growth, protein synthesis, and hypertrophy regulation. N-Coumaroyldopamine & N-caffeoyldopamine can be found in cocoa plants and are known for their strong beta 2-adrenoceptor agonist abilities. One of the very popular and also an illegal drug used among athletes, the Clenbuterol also is a beta2 agonist and carries very similar properties, and this really is something that makes the Compound 20 interesting AND effective. The main effect for the physique is simply increasing muscle mass and decreasing fat mass.

It’s believed to make this happen by activating the same signaling pathways like the IGF-1 and insulin does. Another interesting aspect of the N-Coumaroyldopamine & N-caffeoyldopamine are their ability to potentially modify polyamine levels, wich can create yet another mechanism disabling skeletal muscle atrophy and even enabling direct muscle growth.

Company Information

Qingdao Xigema Chemical Co., Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".Xigema has 21 subsidiaries and holding companies.