High quality Rapamycin with best price 53123-88-9

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High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9
High quality Rapamycin with best price 53123-88-9

High quality Rapamycin with best price 53123-88-9

  • Item No.TOP
    MOQ1 Gram
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From $260.0090.00 / Gram
$260.00
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Quick Details
Product name Rapamycin
MW914.18
Place of Origin CN;SHN
Usage Animal Pharmaceuticals
Boiling point 799.83°C (rough estimate)
Brand Name QDXIGEMA
Model Number TOP
Colorwhite
density 1.0352 (rough estimate)
storage temp. -20°C
Formpowder
Melting point 183-185°C
Shelf Life 2 Years
Refractive Index 1.5280 (estimate)
Grade Standard Medicine Grade
Type Antibiotic and Antimicrobial Agents
CAS No. 53123-88-9
Other Names Rapamycin
MFC51H79NO13
EINECS No. 262-640-9
Purity99%

Packaging & Delivery

Selling Units:
Gram
Product Description

    Product Description

 Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP(RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is

 potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.


 

   Certification of Analysis

Item

Specifications

Results

Description

off-white to yellow crystalline powder

Complies

Identification

The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard

Complies

 

The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm, 277nm, 288nm that of similar preparation of in-house reference standard.

Complies

The retention times of the peaks for the Trans- and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the Assay

Complies

Loss on drying

≤0.5%

0.16%

Heavy metal

≤0.002%

Complies

Total impurity

≤2.0%

0.76%

Single impurity

≤1.0%

0.67%

Cis-stereoisomer of Sirolimus

≤5.0%

2.4%

Assay

≥98.0%

99.2%

Conclusion

The production complies with enterprise standard

 

 

 

Function&Application

Rapamycin is a triene macrolide antibiotic, which demonstrates

anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

 
Company Information

Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

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FAQ
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