Tolvaptan is a selective, competitive vasopressin receptor 2 antagonist with an IC50 of 1.28µM for the inhibition of AVP-induced

platelet aggregation. Tolvaptan is used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the

syndrome of inappropriate antidiuretic hormone. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease.

 Treatment with Tolvaptan causes rapid and sustained body weight reductions concurrent with increases in urine 

output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms 

of congestion and increases thirst. However,Tolvaptan has not been shown to decrease heart failure

 re-hospitalization or mortality. As an adjunct to standard therapy, Tolvaptan is unique in that it is virtually the only 

novel agent tested in patients hospitalized for acute heart failure syndrome to reach its primary end point for short-term

 efficacy without causing deleterious side effects.

Qingdao xigema Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals 

and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".xigema has 21 subsidiaries and holding companies.

Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.

Q2: How to contact with us?
Click the Alibaba "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.

Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account

Q4:Can you give me a discount price?
Surely,It depend on your qty

Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

If you are interested,welcome to contact with us.
Pls send message if you are interested,click "send" as below ^.^