Clofarabine is a purine nucleoside analogue that is a lipophilic derivative of 2-Chloro-2'-deoxyadenosine (sc-202399). The advantage to using this compound compared to 2-Chloro-2'-deoxyadenosine is the increased stability of the acid. Studies suggest that Clofarabine contains the best qualities of Fludarabine (sc-204755) and 2-Chloro-2'-deoxyadenosine, with increased resistance to deamination and phosphorolysis. The compound functions by inhibiting intracellular ribonucleotide reductase and DNA polymerase, which suppresses DNA replication. Furthermore, Clofarabine displays greater affinity towards dCK (deoxycytidine kinase, dCyd), an enzyme essential in nucleoside phosphorylation.
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2 years for Clofarabine
Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed.
Clofarabine should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Clofarabine is used as blood system medicine, cure leukemia.
It is currently the only available drugs for the special treatment of children with acute myelogenous leukemia (ALL); it has an excellent efficacy on the treatment of leukemia with well tolerance and no unpredictable adverse reactions. It can be administrated through either administered intravenously or administered orally. This drug is the first product approved for being dedicated to the treatment of the children's leukemia in more than ten years.
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