Rotundine powder, an analgesic drug, has been entrapped in a PIC polysaccharide granule. It was prepared in a two-step process, i.e., first granulation of a chitosan acetated solution containing Rotundine and then complexation of the polycationic component on the granular surface with a polyanionic solution of carboxymethyl glucomannan (CMGM). The granule has an average diameter of 1.38–1.53 mm and the drug content reaches 62.8%.

Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.