Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price

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Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price
Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price
Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price
Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price
Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price
Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price

Hot sale & hot cake high quality CAS 790299-79-5 Masitinib with reasonable price

  • Item No.99%
    MOQ1 Gram
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Quick Details
Product name Masitinib
Appearance White Solid
MW:498.64
Place of Origin CN;SHN
Usage Animal Pharmaceuticals
Brand Name QDXIGEMA
Model Number 99%
NameMasitinib
storage temp. Refrigerator
Melting point 90-95C
Grade Standard Food Grade
Type Central Nervous System Agents
CAS No. 790299-79-5
Other Names Masitinib
MFC28H30N6OS
EINECS No. 790299-79-5
Purity99%min

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High quality CAS 790299-79-5 Masitinib

 

 

 

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Product Name:Masitinib (AB1010)
Synonyms:MASITINIB;4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide;4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide;Ab 1010;Ab1010;Ab-1010;Mastinib;Masitinib(AB1010)
CAS:790299-79-5
MF:C28H30N6OS
MW:498.64
EINECS: 
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Anti-cancer&immunity;Inhibitors
Mol File:790299-79-5.mol

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Masitinib is a competitive inhibitor against ATP at concentrations ≤500 nM. Masitinib also potently inhibits recombinant PDGFR and the intracellular kinase Lyn, and to a lesser extent, fibroblast growth factor receptor 3. In contrast, Masitinib demonstrates weak inhibition of Abl and c-Fms. Masitinib more strongly inhibits degranulation, cytokine production, and bone marrow mast cell migration than imatinib. In Ba/F3 cells expressing human wild-type Kit, Masitinib inhibits SCF (stem cell factor)-induced cell proliferation with an IC50 of 150 nM, while the IC50 for inhibition of IL-3-stimulated proliferation is at approximately >10 µM. In Ba/F3 cells expressing PDGFRα, Masitinib inhibits PDGF-BB-stimulated proliferation and PDGFRα tyrosine phosphorylation with IC50 of 300 nM. Masitinib also causes inhibition of SCF-stimulated tyrosine phosphorylation of human Kit in mastocytoma cell-lines and BMMC. Masitinib inhibits Kit gain-of-function mutants, including V559D mutant and Δ27 mouse mutant with IC50 of 3 and 5 nM in Ba/F3 cells. Masitinib inhibits the cell proliferation of mastocytoma cell lines including HMC-1α155 and FMA3 with IC50 of 10 and 30 nM, respectively. Masitinib inhibits cell growth and PDGFR phosphorylation in two novel ISS cell lines, which suggest that Masitinib displays activity against both primary and metastatic ISS cell line and may aid in the clinical management of ISS.

 

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Company Information
Qingdao Xigema Chemical Co., Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".Xigema has 21 subsidiaries and holding companies.
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FAQ
Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.
 
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Surely,It depend on your qty
 
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free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
 
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
 
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
 

 

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