Our advantages

High quality 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4triazolo4,3-apyrazine hydroch99% CAS 762240-92-6

1.Competitive price
2.Fast Delivery Within 2 days
3.SGS , BV, GMP,ISO approve
4.Professional factory

Sitagliptin intermedaite
Sitagliptinis an oral antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type

Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal.[12] By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an"overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents.

Sitagliptin has been shown to lower HbA1c level by about 0.7% points versus placebo. It is slightly less effective than metformin when used as a monotherapy. It does not cause weight gain and has less hypoglycemia compared to sulfonylureas. Sitagliptin is recommended as a second line drug (in combination with other drugs) after the combination of diet/exercise and metformin fails.

Qingdao XIGEMA Chemical Co., Ltd. Import And Export Co., Ltd is is a global chemical industry manufacturers
and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals
and fine chemicals etc.The aim of XIGEMA is a quality policy that"Elements in the system all have been satisfied,
Personnel has been trained; Every batch of material is checked,
Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time,
quality and reputation to increase market share and promote enterprise development.
The quality, colors and forms of our products have reached a high level in related chemical industry,
which relies on characteristic and advanced processing technology and it has gained a high
and reliable reputation from customers at both quality and services.
XIGEMA has become the"Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".
XIGEMA has 21 subsidiaries and holding companies.