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Hot selling high quality CAS 171228-49-2 Posaconazole with reasonable price and fast delivery
1-9 Gram
$16.80
≥ 10 Gram
$15.00
- Item No.99%MOQ1 Gram
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High quality CAS 171228-49-2 Posaconazole
1)Product Name:Hot selling 99% Posaconazole cas.171228-49-2 with reasonable price
2)CAS:171228-49-2
3)Molecular Formula:C37H42F2N8O4
4)Molecular Weight:700.7774
5)Assay:99%
6)Appearance:White powder
Test items | Standard | Result | |
Description | White to off- White powder | Conforms | |
Identification | IR | IR spectrum of sample is the same as working standard | Conforms |
HPLC | HPLC RT of the sample is the same as the working standard | Conforms | |
Melting point | 165.0°C~169.0°C | 165.8°C~167.0°C | |
Optical rotation | -23°~-29° | -27.4° | |
Loss on drying | NMT 1.0 % | 0.17% | |
Residue on ignition | NMT 0.1 % | 0.03% | |
Heavy metals | NMT 20ppm | Conforms | |
Related substances | |||
Impurity A | NMT 0.1 % | Not detected | |
Impurity B | NMT 0.1 % | Not detected | |
Impurity C | NMT 0.1 % | 0.02% | |
Single impurity | NMT 0.2 % | 0.17% | |
Total impurity | NMT 1.0 % | 0.60% | |
Assay | NLT 99.0% | 99.0% | |
Posaconazole is a broadspectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and
Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14ademethylase enzyme (IC50s range from 7-
200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for
the function of certain membranebound proteins.Posaconazole is a broad-spectrum, second generation, triazole compound with
antifungal activity. Posaconazole strongly inhibits 14alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a
sterol C14a demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to
ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane
composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole
antifungals, posaconazole is a significantly more potent inhibitor of sterol 14alpha demethylase. Posaconazole is the most advanced
candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.
The aim of Xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
Xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".Xigema has 21 subsidiaries and holding companies.
Answer: Yes, we are factory founded on 2002.
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For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account
Q4:Can you give me a discount price?
Surely,It depend on your qty
Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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