Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!

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Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!
Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!

Hot selling high quality Fasudil Hydrochloride 105628-07-7 with best price!

  • Item No.105628-07-7
    MOQ1 Kilogram
Tag  sourcing
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From $50.00 / Kilogram
$50.00
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Product Description

sigma banner.jpg Introduction

 

Fasudil hydrochloride is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.

 

Specification

 

Solution

 Easily solution in water, solution in methanol

Appearance

White or off-white crystalline powder

Assay

99%min

 Indentification

 

 UV

 Meets the requirements

 IR

 Consistent with reference specturm

 Chemical reaction

 Meets the requirements

 Color or solution

 not more intensely colored than refrence solution  Y1

 Clarify of solution

 not more palescent than refrence suspension solution 

Related substance

single impurity: 0.1%max

 

Total impurity:1.0%max

PH

4.5-6.0

Dimethylformamide

0.088%max

Aether

0.5%max

Methanol

0.3%max

Dichloromethane

0.06%max

Moisture

2.5%max

Residue on ignition

0.1%max

Heavy metals

0.002%max

Packaging & Shipping

2

 

 

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Our Services

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Company Information

Qingdao Xigema Chemical Co., Ltd. Import And Export Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Xigema is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Qingdao Xigema has become the"Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".Qingdao Xigema has 21 subsidiaries and holding companies.

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FAQ

Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.
 
Q2: How to contact with us?
Click the Alibaba"Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.
 
Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account
 
Q4:Can you give me a discount price?
Surely,It depend on your qty
 
Q5:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
 
Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
 
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.


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