Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
1-1000 Kilogram
$32,360.00
≥ 1001 Kilogram
$32,352.00
- Item No.SaxagliptinMOQ1 Kilogram
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If over 500pcs, mass production will start until pre-production sample has been approved.
Est. 7 days production
2.Fast Delivery Within 2 days
3.SGS , BV, GMP,ISO approve
4.Professional factory
Introduction of Saxagliptin :
Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
Specificationof Saxagliptin :
Test | Specifications | Result |
Assay Content % by HPLC | Min.98% | 99.08% |
Appearance | white powder | Complies |
Odor | Characteristic | Complies |
PH | 5.0-7.0 | 6.09 |
Clarity of water solution | Transparent, colorless, none suspended matters | Complies |
Loss on drying % | MAX 0.5 | 0.25 |
Ash % | MAX.0.5 | 0.38 |
Melting point | +202.0-212.0°C | Complies |
Specific rotation | +174.0-+186.0 | +181.0 |
Hydroquinone | Negative | Complies |
Heavy metals PPM | MAX.10 | Complies |
As AAS Pb Cd | <2ppm <1ppm <1ppm | Complies Complies Complies |
Microbiology Total Plate Count Yeast & Mold E.Coli S. Aureus Salmonella |
<1000cfu/g <100cfu/g Negative Negative Negative |
122 cfu/g 13 cfu/g Complies Complies Complies |
Conclusion | Conform with specification |
Functionof Saxagliptin:
Pharmacodynamics:
Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period. It also decreased glucagon concentrations and increased glucose-dependent insulin secretion from pancreatic beta cells. The half maximal inhibitory concentration (IC50) is 0.5 nmol/L. Saxagliptin did not prolong the QTc interval to a clinically significant degree.
Mechanism of Action:
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
9. After-Sale Service:
(1) International Authorized Third-Party Test For The Products You Demand.
(2) 60 Days Warranty of quality of goods.
Shipping Terms | ||
By Express | By Air | By Sea |
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods | Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed | Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed |
1. Your inquiry related to our products or prices will be replied in 12hours.
2. Well-trained and experienced staffs to answer your enquires in fluent English.
3. All our products have high quality warranties.
4. Sample order can be delivered within 3 working days, small order 3-5working days, mass order 7-10working days.
5. Samples can be offered by free,customers just need to pay the freight.But the freight can be returned to our customer after he/she places formal order with us.
Qingdao xigema Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals
and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".xigema has 21 subsidiaries and holding companies.
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