Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!

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Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!
Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!

Hot selling high quality Saxagliptin 361442-04-8 with reasonable price and fast delivery !!

  • Item No.Saxagliptin
    MOQ1 Kilogram / Kilogram
Tag  sourcing

Quantity:

From $32360.0032352.00 / Kilogram
$32,360.00
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Quick Details
Product name Saxagliptin
Appearance White Powder
Place of Origin CN;SHN
Usage Animal Pharmaceuticals
Boiling point 548.7°C at 760 mmHg
Brand Name xigema
Model Number Saxagliptin
Vapour Pressur 2.51E-14mmHg at 25°C
Flash point 285.6°C
density1.35g/cm3
Molecular Weight 315.41
Storage Cool and dry
Shelf Life 24 Months
Refractive Index 1.64
Grade Standard Medicine Grade
Type Antibiotic and Antimicrobial Agents
CAS No. 361442-04-8
Other Names Saxagliptin
MFC18H25N3O2
EINECS No. /
Purity99%min
Specifciation
 
1.Competitive price
2.Fast Delivery Within 2 days
3.SGS , BV, GMP,ISO approve
4.Professional factory
 
Product Description

Introduction of Saxagliptin :

 

Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.

 

Specificationof Saxagliptin :

 

Test

Specifications

Result

Assay  Content % by HPLC

Min.98%

99.08%

Appearance

white powder

Complies

Odor

Characteristic

Complies

PH 

5.0-7.0

6.09

Clarity of water solution 

Transparent, colorless, none suspended matters

Complies

Loss on drying %

MAX 0.5

0.25

Ash %

MAX.0.5

0.38

Melting point 

+202.0-212.0°C

Complies

Specific rotation 

+174.0-+186.0

+181.0

Hydroquinone 

Negative 

Complies 

Heavy metals PPM

MAX.10

Complies 

As          AAS

Pb        

Cd

<2ppm

<1ppm

<1ppm

Complies

Complies

Complies

Microbiology

Total Plate Count

Yeast & Mold

E.Coli

S. Aureus

Salmonella

 

<1000cfu/g

<100cfu/g

Negative

Negative

Negative

 

122 cfu/g 

13 cfu/g

Complies

Complies

Complies

Conclusion

Conform with specification

 

Functionof Saxagliptin:

 

Pharmacodynamics:

 

Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period. It also decreased glucagon concentrations and increased glucose-dependent insulin secretion from pancreatic beta cells. The half maximal inhibitory concentration (IC50) is 0.5 nmol/L. Saxagliptin did not prolong the QTc interval to a clinically significant degree.

 

Mechanism of Action:

 

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

 

Our Advantages

1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
9. After-Sale Service:
(1) International Authorized Third-Party Test For The Products You Demand.
(2) 60 Days Warranty of quality of goods.

Packaging & Shipping

 

                                   Shipping Terms                                                   

              By Express

                     By Air

                  By Sea

      Suitable for under 50kg

      Fast: 3-7 days

 

      High cost

      Door to door service,

      easy to pick up the goods

      Suitable for more than 50kg

      Fast: 3-7 days

      High cost

      Port to port, 

      professional broker needed

    Suitable for more than 500kg

    Slow: 7-45 days

    Low cost

    Port to port, 

    professional broker needed

 

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Our Services

1. Your inquiry related to our products or prices will be replied in 12hours.

2. Well-trained and experienced staffs to answer your enquires in fluent English.

3. All our products have high quality warranties.

4. Sample order can be delivered within 3 working days, small order 3-5working days, mass order 7-10working days.

5. Samples can be offered by free,customers just need to pay the freight.But the freight can be returned to our customer after he/she places formal order with us.

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Company Information

 

Qingdao xigema Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals 

and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".xigema has 21 subsidiaries and holding companies.

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