Pharmaceutical grade prostaglandin e1 alprostadil with best price 745-65-3
≥1 Gram
$600.00
- Item No. TOPMOQ 1 Gram
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If over 500pcs, mass production will start until pre-production sample has been approved.
Est. 7 days production
The main component of this product is prostaglandin E1, its chemical name is (1R, 2R, 3R) -3-hydroxy-2 (E) - (3S) -3-hydroxy-1-octenyl- Alkanoic acid.
Alprostadil injection for the treatment of chronic arterial occlusion caused by limb ulcers and microvascular circulatory disorders caused by resting pain in the limbs, improve cardiovascular and cerebrovascular microcirculation disorders. Antithrombotic therapy after organ transplantation to inhibit thrombosis in transplanted blood vessels. Pediatric congenital heart disease patent ductus arteriosus, to alleviate hypoxemia, keep the catheter to wait for the timing of surgical treatment
Tests and Methods | Specifications | Results |
Appearance | White or slightly yellowish,crystalline powder. | Conforms |
Identification | ||
(1) HPLC | The retention time of the major peak in the chromatogram of Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay | Identical |
(2) IR absorbance Spectrum | Both the test sample and the reference standard exhibit the same intensity of absorption at the same wave number (wavelengths). (potassium bromide disk method) | Identical |
Optical rotation | -60° to -70° (anhydrous substance). | -62.56° |
Water | N.M.T. 0.5% | 0.09% |
residue on ignition | N.M.T. 0.5% | 0.35% |
Purity | 99% | 99% |
1) Related Substances | Impurity A: N.M.T. 1.5% | Not detected |
Impurity B: N.M.T. 0.5% | Not detected | |
Any other impurity: N.M.T. 0.9% | Not detected | |
N.M.T one Impurity more than 0.5% | Conforms | |
Total Impurities: N.M.T. 1.5% | Not detected | |
2) Residual solvents | Ethyl acetate: N.M.T. 0.5% | 0.22% |
N-heptane:N.M.T. 0.5% | 0.01% | |
Acetone: N.M.T. 0.5% | Not detected | |
n-Hexane: N.M.T. 0.029% | Not detected | |
Assay | 95.0~102.5% ( anhydrous and solvent free basis) | 99.90% |
Conclusion: conforms to the requirements of EP7.0 |
Alprostadil injection is indicated for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atresia, tetralogy of Fallot, interruption of the aortic arch, coarctation of the aorta, or transposition of the great vessels with or without other defects.
In infants with restricted pulmonary blood flow, the increase in blood oxygenation is inversely proportional to pretreatment pO2 values; that is, patients with low pO2 values respond best, and patients with pO2 values of 40 torr or more usually have little response.
Alprostadil injection should be administered only by trained personnel in facilities that provide pediatric intensive care.
Qingdao Sigma Chemical Co., Ltd.is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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Answer: Yes, we are factory founded on 2002.
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free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
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