Top quality Calcium folinate with best price 1492-18-8



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Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8
Top quality Calcium folinate with best price 1492-18-8

Top quality Calcium folinate with best price 1492-18-8

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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Product Description

V2-Product Profile

product NameCalcium folinatc
SynonymsFolinic acid Calcium salt; calcium folinate; Folinic acid calcium salt USP28; Calcium leucovorin; LeucovorinCalcium; CALCIUM FOLINATE(FOLINIC ACID)(RG); Leucovorin Calcium; calcium2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl] aminopentanedioate; L-Calcium Folinate; Calcium L-Folinate; calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate; calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate
Molecular FormulaC20H21CaN7O7
Molecular Weight511.5014
CAS Registry Number1492-18-8
Molecular Structure 
Hazard Symbols Xn:Harmful;
Risk CodesR36/37/38:;
Safety DescriptionS26:;



Appearanceyellowish-white oryellow,ordorless powder conforms
identification IR conforms conforms
solubility Very soluble in water0.92%g/ml practically insoluble in alcohol 
heavy metals NMT0.005% <0.005%
water content NMT17.0% 10.4%
assay of Ca 7.54%-8.14% 7.62%
Assay 95.0%-105.0% of C20H21CaN7O7 Calculated on the anhydrous basis 99.3%


Folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may"rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. No apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity. Folinic acid can be taken as a pill (orally) or injected into a vein (intravenously) or muscle (intramuscularly). 
While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be redosed until the methotrexate level is less than 5 x 10−8 M.
Additionally, folinic acid is sometimes used to reduce the side effects of methotrexate in rheumatoid arthritispatients. This includes reductions in nausea, abdominal pain, abnormal liver blood tests, and mouth sores. 
Folinic acid is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for"rescue" purposes; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase.
Folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine. It may be prescribed in the treatment oftoxoplasmosis retinitis, in combination with the folic acid antagonists pyrimethamine and sulfadiazine.
Folinic acid has dextro- and levorotary isomers, only the latter one being pharmacologically useful. As such, levoleucovorin was approved in 2008.
It has been investigated for use in Down syndrome, but a benefit has not been demonstrated. 
Company Information

Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.


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