Top quality Donepezil/Donepezil hcl with best price 120014-06-4



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Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4
Top quality Donepezil/Donepezil hcl with best price 120014-06-4

Top quality Donepezil/Donepezil hcl with best price 120014-06-4

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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Product Description


Basic Information

Product name                Donepezil

Appearance:                  White or off-white crystalline powder

CAS NO.                       120014-06-4

Molecular Formula         C24H29NO3

Molecular Weight           379.49200

Melting point                  207ºC

Boiling point                   527.9ºC at 760mmHg

Density                          1.141g/cm3

Flash point                     273.1ºC


Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs


Test Report






White or almost white crystalline powder



A: By IR, To match with working standard



B: By UV, To match with working standard.


Melting point



Residue on ignition


≤ 0.2%

Heavy metals

< 0.001%

≤ 0.001%

Related substances


≤ 1.0%



≤ 1.0%






FunctionMild or moderate Alzheimer-type dementia treatment.

Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs.


AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons,such cholinergic theory has been confirmed by histological study. Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites.


Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide,neurotransmitter receptors, or Ca2 + channels.

Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger,it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect,probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.


Application Area1. adult / elderly: initial treatment dosage 5mg / day (day 1). The product should be orally at bedtime at night. 

Doses of 5mg / day should be maintained at least - months to evaluate early clinical response, and donepezil hydrochloride reach steady-state plasma concentrations. After using 5mg / day treatment a month, making clinical evaluation may be the product of the dose to 10mg / day (day 1). The maximum recommended dose is 10mg.

Greater than 10mg / day dose clinical trials have not done. We did not conduct placebo-controlled clinical trials with more than six months. After stopping treatment, the efficacy of the product gradually diminishes. Discontinuation of treatment no rebound phenomenon.

2. liver and kidney damage: For mild to moderate renal and hepatic dysfunction, donepezil hydrochloride elimination is not affected, so these patients can use a similar dose schedule.



Company Information
Qingdao Sigma Chemical Co., a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that"Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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