1-1000 Kilograms
$1,000.00
≥1001 Kilograms
$800.00
Product Description
Product Name | Dirithromycin |
Appearance | crystals |
CAS NO. | 62013-04-1 |
Molecular Formula | C42H78N2O14 |
Molecular Weight | 835.07 |
Density | 1.19 g/cm3 |
Melting Point | 185 - 189ºC |
Boiling Point | 871.8ºC at 760 mmHg |
Flash Point | 481ºC |
Assay | 99% min |
Certification of Analysis
Characteristics | A white or almost white, crystalline powder |
| Soluble in water |
Identification | The retention time of major peak in the chromatogram of the sample corresponds to the standard |
| IR |
Dirithromycin 15S-epimer% | ≤1.5 |
Heavy metals | ≤20ppm |
Water% | ≤1.0 |
Sulphated ash% | ≤0.1 |
Impurities% | 9-(S)-erythromycylamine ≤1.5 |
| Other single impurity ≤1.0 |
| Total impurities ≤4.0 |
Assay% | 96.0~102.0 |
Particle size | 100% through 60 or 80 mesh sieve |
Residual solvent | Acetonitrile≤0.1% |
Ethyl ether≤5000ppm | |
Dichloromethane≤600ppm | |
Methanol≤3000ppm | |
2-propanol≤5000ppm |
Function&Application
Dirithromycin is a macrolide antibiotic pro-drug of 9S-erythromycylamine, a close analogue of erythromycin in which the 9-keto group is replaced with an amino group in the S-configuration. Although erythromycylamine overcomes the acid instability of erythromycin, it is poorly absorbed following oral administration. Dirithromycin is formed by reacting erythromycylamine with an aldehyde to form a Schiff base which undergoes cyclisation to an oxazine with the C11-alcohol. Dirithromycin provides higher tissue levels and prolonged in vivo half-life by slowly releasing erythromycylamine.
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