Top quality Capecitabine with best price 154361-50-9
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    Other name: Pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate

    CAS NO.:154361-50-9

    MF:C15H22FN3O6

    MW: 359.35

    InChI: 1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)

    Melting point: 110~121℃

    Appearance:white or off-white crystalline powder

    Specification:99%min

    Standard: EP/BP/USP

    Odor: odorless

       Certification of Analysis

     

     

    Items

    Specifications

    Results

    Appearance

    A white or off white crystalline powder

    White crystalline powder

    Solubility

    Freely soluble in chloroform

    Conform

    Specific rotation(0)[α]D20

    +75~+84

    +78.6

    Loss on drying(%)

    ≤1.0

    0.73

    Residue on ignition(%)

    ≤0.1

    0.03

    Heavy metals(ppm)

    ≤20

    conform

    Metling point()

    178-193 centi-degree

    186-190centi-degree

    Purity(HPLC,%)

    ≥98.0

    99.6%

    Related substances(HPLC)

    Single impurity: ≤0.5%

    Total impurity: ≤1.0%

    Conform

     

    Function&Application

     

    Function:

    Classification: Antineoplastic, antimetabolite Action/Kinetics: An oral prodrug of 5'-deoxy-5-fluorouridine (5'DFUR) that is converted to 5-fluorouracil (5-FU). 5-FU is metabolized to 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) which cause cell injury in two ways. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase to form a covalently bound ternary complex which inhibits the formation of thymidylate from uracil. Thymidylate is essential for the synthesis of DNA so a deficiency inhibits cell division. Secondly, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate during RNA synthesis; this interferes with RNA processing and protein synthesis. Readily absorbed from the GI tract. Peak blood levels, capecitabine: 1.5 hr; peak blood levels, 5-FU: 2 hr. Food reduces the rate and extent of absorption. t1/2, capecitabine and 5-FU: 45 min. Metabolites excreted in the urine.

    Application  

     1. Natural d alpha tocopherol, Tocopherol Powder Applied in the Cosmetics industry, mixed tocopherol can prevent the premature aging of skin and improve the skin's elasticity.
    2. Natural d alpha tocopherol, Tocopherol Powder Applied in the Medical industry, mixed tocopherol can be used in curing pericoronitis, fatty liver, and arteriosclerosis, habitual abortion and barrenness.
    3. Natural d alpha tocopherol, Tocopherol Powder Applied in the Food industry, mixed tocopherol is mainly used as an antioxidant and a fortifying agent of fatty foods,and nutritional reinforcing agent of health care product.
    4. Natural d alpha tocopherol, Tocopherol Powder Applied in feed additive for livestock, mixed tocopherol is mainly used as an antioxidant it can improve the reproductive functions of animals and increase reproductive capacity.

      

     

    Real Photo

    1

    Company Information

    Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
     
    The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

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    Packaging & Shipping

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    FAQ
    Q1: Are you a manufacturer?
    Answer: Yes, we are factory founded on 2002.
     
    Q2: How to contact with us?
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    Q4:Can you give me a discount price?
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    free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
     
    Q6: How to confirm the Product Quality before placing orders?
    A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
     
    Q7:How do you treat quality complaint?
    A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
     
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