10-1009 Grams
$5.00
≥1010 Grams
$1.00
1)Product Name:Natural Nootropics Agomelatine powder CAS 138112-76-2
2)Purity:99%
3)Testing Method:HPLC
4)Molecular Formula:C15H17NO2
5)Introduction:
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.
Agomelatine is one kind of off-white or white crystalline powder or white solid. The IUPAC Name of this chemical is N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. This chemical belongs to Aromatics Compounds;Aromatics;Neurochemicals;APIS. It should be store at -20°C Freezer. Agomelatine Solubility: Soluble in Chloroform and Methanol. DMSO ≥49mg/mL Water <1mg/mL Ethanol ≥49mg/mL.
As a Pharmaceutical Intermediates, Agomelatine is used in the treatment of major depressive disorder, emotional disorder. Agomelatine is used in the treatment of major depressive disorder, emotional disorder. The drug substance for Nervous system. Antidepressant, anxiolytic, adjusting the rhythm of sleep and regulating biological clock. Agomelatine is a melatoninergic agonist and selective antagonist of 5-ht2c receptors. Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.
ITEM | STANDARD | RESULTS |
Appearance | White to almost white crystalline powder | white crystalline powder |
Solubility | This product is soluble in DMF, methanol, ethanol, water and 0.1mol/L hydrochloric acid solution almost not | 108.4-108.5 C |
UV | Has an absorption maximum at 230nm | Conforms |
IR | Corresponding to reference spectrum | Conforms |
Chloride | ≤0.01% | Conforms |
Single impurity | ≤0.5% | 0.049% |
Total impurity | ≤0.1% | 0.06% |
Impurities I | ≤0.1% | Not detected |
Impurities II | ≤0.1% | Not detected |
N-hexane | ≤0.029% | 0.0002% |
Ethanol | ≤0.5% | 0.1% |
Dichloromethane | ≤0.06% | Not detected |
Ethyl acetate | ≤0.5% | Not detected |
Tetrahydrofuran | ≤0.072% | Not detected |
Toluene | ≤0.089% | Not detected |
Chloroform | ≤0.006% | 0.001% |
Loss on drying | ≤0.5% | 0.002% |
Residue on ignition | ≤0.1% | 0.06% |
Heavy metal | ≤20ppm | Conforms |
Assay | ≥99.0% | 99.52% |
Conclusion | Qualified | |
Agomelatine can help regulate your'body clock' (circadian rhythm) with positive benefits on mood and sleepin depression Agomelatine is used in the treatment of depression or to help prevent depression returning, and isonly available with a doctor's prescription. The symptoms of depression vary from one person toanother, but commonly include persistent sadness, loss of interest in favourite activities, feelings of worthlessness, sleep problems, feeling of being slowed down, feelings of anxiety or changes in appetite and weight. Changes in your daily sleep and appetite patterns are examples of disturbances of your body clock that occur commonly indepression
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