Top quality best price CAS: 90779-69-4 Atosiban
  • Item No.Atosiban
    MOQ1 Kilogram / Kilograms
    description
    Product Description
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    1).Product:  Atosiban

    2).CAS:  90779-69-4  

    3).MF:  C45H71N11O14S2

    4).Apperance:White powder

    Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. Originally it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.
    Functions

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    Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).

    Atosiban inhibits the oxytocin-mediated release of inositol trisphosphatefrom the myometrial cell membrane.
    Atosiban is useful in improving the pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with repeated implantation failure (RIF). The pregnancy rate improved from zero to 43.7%.

    Analysis

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    TEST  ITEMS

    STANDARD PRESCRIBE

    RESULTS

    Description

    White or almost white fluffy powder,hygroscopic

    white fluffy powder,hygroscopic

    identification

    The pricipal peak in the chromatogram obtained the test solution is similar in retention time and size to the pricinpal paek in the chromatogram obtained with reference solution(HPLC)

    Confroms

    Specific rotation

    -45.°~ -55°

    -50.5°

    Acetic acid

    ≤10.0%

    5.5%

    Water (K.F)

      ≤6.0%

    4.0%

    Related petides(HPLC)

    Individual impurity≤1.0%

    0.26%

    Total impurities≤2.0%

    0.69%

    Residue organic solvents

    ≤0.5% aether
    ≤0.041%acetonitrile

    ≤0.06%methylene chloride

    ≤0.088%N’N-Dimethylformamide

    0.041%

    0.004%

    ND

    ND

    Bacterial endotoxin

    <5.0 EU/mg

    <5.0 EU/mg

    Assay

    97.0~103.0%

    (anhydrous ,acid-free)

    99.9%

    Conclusion :

    Comply with the in-house standard 

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