Product Description

Marbofloxacin is a new type of fluoroquinolone antibiotic, by inhibiting bacterial DNA transcription to inhibit the growth of bacteria, it also has antibacterial activity to the gram-negative 

bacteria, gram positive bacteria and mycoplasma. Marbofloxacin can be absorbed by 

oral and injected drugs, and has low toxic and side effect.

1. Pharmacodynamics: wide antimicrobial spectrum, strong antibacterial activity. the MIC90 of most enterobacteriaceae, multiple kill Pasteur's bacteria, pseudomonas aeruginosa, golden yellow staphylococcus and staphylococcus aureus were 0.08 ~ 0.28, 0.04, 0.94, 0.2, and 0.23 mu g/mL, fairly to ciprofloxacin and enrofloxacin. The MIC90 of bovine respiratory pathogens such as kill more sexual Pasteur's bacteria, hemolytic Pasteur's bacteria, lethargy haemophilus and mycoplasma were 0.02, 0.02, 0.03 and 0.48 mu g/mL. The product is still valid to some drug-resistant pathogenic bacteria such as erythromycin, clindamycin, chloramphenicol, doxycycline, sulphonamide pathogen.

2. Pharmacokinetic: absorbed quickly and completely after injection and oral, combining with plasma proteins in low rate, wide distribution in the tissue, distribution in the kidney, liver, lungs and skin is good, its concentration in plasma and tissue is higher than most pathogens’ MIC. The oral bioavailability of pregnant sows and cat is about 80%, calf is above 100%. This product has a large distribution volume (more than 1.3 L/kg), except the central nervous, the drug concentrations of all tested tissue are higher than plasma. Part in hepatic is metabolism into inactive metabolites (N - methyl MBF and N - oxygen MBF). Main excretion way is through kidney, there is about 30%--45% drug prototype in dogs’ urine. Half-life is long, for dogs’ oral and subcutaneous injection, it can be 14 hours and 13hours, for calves (intramuscular injection), chicken (intramuscular injection), the sow (oral), cat (oral), it can be 4.33, 5.26, 5.74 and 10 h. So the effective blood drug concentration can maintain for a long time after doseing.

                  Certification of Analysis

 Function&Application

Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands, as well as with urinary tract infections in dogs and cats. For dogs, a dose of approximately 2 mg/kg is used. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.

Qingdao Xigema Chemical Co., Ltd is a global chemical industry manufacturer and a supplier of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global agrochemical sales".Xigema has 21 subsidiaries and holding companies.