Rosiglitazone is an insulin sensitizer of thiazolidinedione, and its mechanism is related to the specific peroxidase proliferation factor activator. By increasing the skeletal muscle, liver, adipose tissue insulin sensitivity, improve the glucose utilization in cells and exert the effect of lowering blood sugar, can obviously reduce the fasting blood glucose and insulin and c-peptide levels, the postprandial blood glucose and insulin also has lower effect.