Hot selling high quality Glibenclamide 10238-21-8 with reasonable price and fast delivery !!

1-9 Kilograms

$78.60

≥10 Kilograms

$71.50

  • Item No.TOP GRADE
    MOQ1 Kilogram / Kilograms
    description

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    High quality Glibenclamide

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    Product Description

    QQ20190416134021 

    Glibenclamide 
    CAS No: 10238-21-8 
    MF: C23H28ClN3O5 
    Appreance:White crystalline powder

     

    Basic Information

    Basic Information.png 

    Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turnstimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker.Thiscompound inhibits recombinant CFTR Cl- channels

     

     

    ITEM

    STANDARD

    RESULTS

    Appearance

    Crystalline powder

    Conforms

    Melting range

    129°C~132°C

    130.8°C-131°C

    Loss on drying

    ≤0.5%

    0.20 %

    Specific rotation

    -58°~-62°(C=1,in CH3OH)

    -61.05°

    Sulphated ash

    ≤0.1%

    0.08 %

    Heavy metals

    ≤10ppm

    Conforms

    Chlorides

    ≤0.02%

    Conforms

    Sulfates

    ≤0.02%

    Conforms

    Fluorine

    14.7%~17.9%

    15.2%

    Residual solvent

    Methanol ≤0.2%

    Isopropanol ≤0.2%

    Ethyl acetate≤0.2%

    Chloroform ≤0.2%

    0.0%

    0.0%

    0.0%

    0.0%

    Related substances

    (HPLC)

    Single impurity ≤0.2%

    Total impurities ≤0.5%

    0.05%

    0.08%

    Assay

    ≥99.5%

    99.92%

    Conclusion

    Accordance with the reference

     

    Functions

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    Glibenurea can inhibit glycogen decomposition and glycogen differentiation by increasing the insulin level of the portal vein or directly acting on the liver, and the hepatic generation and output glucose decrease. Oral absorption is fast, and the binding rate of protein is very high, which is 95%. After oral administration, the blood concentration reaches a peak of 2 ~ 5 hours and lasts for 24 hours. T1 over 2 is 10 hours. In liver metabolism, liver and kidney excretion each about 50%.

     

    Real shot

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    Packaging & Shipping

     

     

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    Our Services

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    Company Information

    Company Information

     

    QingdaoxigemaCHEMICAL Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
     
    The aim of  xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
     
     xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global agrochemical sales". xigema  has 21 subsidiaries and holding companies.

     

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    FAQ

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