GMP Factory supply API ISOTRETINOINe / Isotretinoine powder
  • Item No.TOP
    MOQ10 Gram / Grams
    description
    Product Description

     

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    1)Product Name:Factory suppply Isotretinoin powder/retinoic acid powder CAS 4759-48-2

    2)Appearance: An orange yellow or yellow, crystalline powder

    3)Active ingredients: Isotretinoine

    4)Specification:98.5%

    5)Test method:HPLC

    6)Introduction:

    Isotretinoine (13-cis-Retinoic acid )is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. Clinically, 13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne. Its effects include reducing the production of sebum, shrinking the size of the sebaceous glands, stabilizing keratinization, preventing comedones from forming, and reducing inflammation of inflammatory acne. Though the exact mechanism of action of 13-cis-Retinoic acid is not fully understood, studies have suggested that the compound alters DNA transcription and induces apoptosis in select types of cells throughout the body.

    Basic Information

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    Test/ObservationSpecificationsResult

    Assay  Content HPLC
    97%-102%99.12%
    AppearanceFine PowderComplies
    IdentificationIR. UVComplies
    OdorCharacteristicComplies
    Mesh100% pass 100 meshComplies
    Residue on ignitionMAX 0.1%Complies
    Loss on drying %MAX 0.5%0.39%
    Ash %MAX. 1.0%0.52%

    Heavy metals PPM

    MAX. 0.002%

    Complies
    Limit of IsotretinoinMAX5.0%3.9%
    Organic Volatile ImpuritiesMeet The RequirementsComplies

    Microbiology

    Total Plate Count

    Yeast & Mold

    E. Coli

    Salmonella

     

    < 1000cfu/g

    < 100cfu/g

    Negative

    Negative

     

    82cfu/g

    Negative

    Complies

    Complies
    Functions

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    Both tretionirum and Vitamin A can stimulate skin growth and keep epidermic normal. Howerver, to spread on part of skin has no actual effect. Taking orally vitamin A is benefit to treat skin disorders. Applying vitamin A acid to skin partly could produce intensive pharmacological action. External use can slow down skin aging process for solarization, remove tiny wrinkles, and reduce skin roughness, so skin will become ruddy. 
     
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    Company Information

    Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
     
    The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

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