1-1000 Grams
$70.00
≥1001 Grams
$40.00
Cabazitaxel | CAS 183133-96-2 | Color:White |
MW: 835.93 | MSDS: Avaiable | |
MF :C45H57NO14 | Sample: Avaiable | |
Category: Oncology drug | Min order: 1grams | |
Quality standard Enterprise standard | Place of Origin:China | |
Appearance | White powder | |
Introduction | is a semi-synthetic derivative of a natural taxoid.It was developed by Sanofi-Aventis and was approved by the U.S. Food and Drug for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy. | |
Applications | Pharmaceutical raw materials , Oncology drug |
TEST ITEM | SPECIFICATION | |
Appearance | White or almost white crystalline powder | |
Identification | FT-IR | |
HPLC | ||
Water | 3.0% | |
Melting Point | 148°C—158°C | |
Residue on Ignition | ≤0.1% | |
Heavy metals | ≤ 20ppm | |
Residual Solvents | Acetone | ≤ 5000ppm |
Dichloromethane | ≤ 600ppm | |
n-Hexane | ≤ 290ppm | |
Acetic acid | ≤ 5000ppm | |
Ethyl acetate | ≤ 5000ppm | |
Tetrahydrofuran | ≤ 720ppm | |
Ethanol | ≤ 5000ppm | |
Related substances | cabazitaxel | ≤ 0.3% |
10-DABIII | ≤ 0.3% | |
Any other single impurity | ≤ 0.1% | |
Total impurities | ≤ 1.0% | |
Chromatographic purity(By HPLC) | ≥99.0% |
Cabazitaxel (previously XRP-6258) is a semi-synthetic derivative of a natural taxoid. It was developed by Sanofi-Aventis and was approved by the U.S for the treatment of hormone-refractory prostate cancer on June 17, 2010. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.
Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment.
Cabazitaxel anticancer mechanism and characteristics similar with docetaxel, belongs to anti-microtubule drugs. Cabazitaxel through binding to tubulin, promoting their assembly into microtubules, and can prevent these have assembled a microtubule disintegration of the stabilization of microtubules, thereby inhibiting cell mitosis, and interphase cellular functions (interphasecellularfunctions) of play.
Qingdao Sigma Chemical Co., Ltd.is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
Scan the QR code with your phone, or visit the URL