Gentamycin sulfate is a kind of aminoglycoside drug, which ACTS on the ribosome in the bacteria, inhibits the synthesis of bacterial proteins, and destroys the integrity of bacterial cell membrane. This medicine can first hole by passive diffusion through the cell's outer membrane proteins, and then by the transportation system, through the cell membrane into the cell is not reversible to combine to the separation of the 30 s subunit ribosomal, causes the destruction of A bit, then:

(1) prevent the correct positioning of aminoacyl tRNA in A bit, especially the binding of methionyl tRNA, which interferes with the assembly of functional ribosomes and inhibits the formation of the 70s initiation complex.

(2) induced tRNA matching with triplet mRNA password mistake, lead to complete the 30 s subunit ribosomal wrong read the genetic code, error caused by amino acid into the protein structure, result in abnormal, without a functional protein synthesis.

(3) inhibit the combination of termination factor and A, so that the synthesized peptide chain cannot be released and prevent the complete ribosomal dissociation.

(4) preventing the polymerization and assembly process of polyribosomes, resulting in the depletion of ribosomes in bacteria.

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Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
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