Factory supplt High purity Doxorubicin Adriamycin/Doxorubicin hydrochloride,CAS 25316-40-9
  • Item No.High Purity
    MOQ1 Kilogram / Kilograms
    description

          High Purity Doxorubicin hydrochloride

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    Product Description

     

                                            Product profile

    CAS No:25316-40-9
    AHFS Codes:10:00.0
    Synonyms:(8S,10S)-10-((3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
    ATC code:L01DB01
    Molecular Weight:579.983 g/mol
    PubChem:31703
    Chemical Formula:C27-H29-N-O11.Cl-H
    DrugBank:DB00997
    Assay/Purity:Typically NLT 98%
    IUPAC Name:(8S,10S)-10-(4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
    SMILES:C[C,H]1[C,H]([C,H](C[C,,H](O1)O[C,H]2C[C,,](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O.Cl
    InChl:1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

     

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                                      Product of Description 

     

        Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9. Orange-Red Crystalline Solid.Used as an antineoplastic.Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA.

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    Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.Antibacterial;DNA intercalant.Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.

     

                                                         Function

         Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.

     

     

     

     

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    Qingdao xigema Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals 

    and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

    The aim of xigema is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

    xigema has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".xigema has 21 subsidiaries and holding companies.

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