10-1009 Grams
$7.00
≥1010 Grams
$1.00
| Productname | Amiloride hydrochloride |
| CAS NO. | 2016-88-8 |
| Synonym | Arumil;AMipraMizi;AMIPRAMIDIN;amiprazidine;AMIPRAMIZIDE;AMipraMidine;GUANAMPRAZINE;AMILORIDE HCL;amiloridechloride;HCL AMILORIDE HCL |
| Category | Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug |
| Standard | Medical standard |
| Appearance | Yellow or yellow green crystalline powder |
Amiloride is a potassium-sparing diuretic, used in the management of hypertensionandcongestive heart failure. Amiloride was also tested as treatment ofcystic fibrosis.
Mechanism of Action:
Amiloride works by directly blocking the epithelial sodium channel(ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in thekidneys (this mechanism is the same for triamterene).This promotes the loss of sodium and water from the body, but without depletingpotassium. The drug is often used in conjunction with thiazide(e.g.co-amilozide) or loop diuretics(e.g.co-amilofruse). Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) is occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitorsorspironolactone. Patients are also advised not to use potassium-containing salt replacements.Amiloride also carries the risk of developing an acidosis.
Item | Specifications | Results |
Appearance | Yellow or yellow green crystalline powder | Yellow green crystalline powder |
Identification | A.The solution appears yellow | Conforms |
B.IR:consistent with the spectrum obtained with .Rimantadine Hydrochloride RS | ||
C.Specific Reaction of chloride | ||
Sulphates | NMT0.05% | Conforms |
Toluene | NMT890ppm | Not detected |
Methanol | NMT3000ppm | Not detected |
Related substances (TLC) | NMT1.0% | Conforms |
Loss on drying | NMT0.5% | 0.07% |
Sulphated ash | NMT0.1% | 0.09% |
Ammonium | NMT0.08% | Conforms |
Heavy metals | NMT0.001% | Conforms |
Assay(On dry basis) | 99.0%-101.0% | 99.58% |
Solubility | Freely Soluble in Chloroform and methanol, soluble in 95% ethanol an water. | Conforms |
Microbiology | Total bacterial count:<1000CFU/g | 30CFU/g |
Total Fungus count: <100CFU/g | <10 CFU/g | |
Escherichia coli:Not detected | Not detected | |
Conclusion | The results conforms with Russian Registration Specification. | |
Qingdao Sigma Chemical Co., Ltd.is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
Qingdao Sigma Chemical Co., Ltd has become the "Top 500 Chinese manufacturing companies",
"Top 20 of global chemical sales".Qingdao Sigma Chemical Co., Ltdhas 21 subsidiaries and holding companies.
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