Manufacturer high quality Pyridoxal 5'-phosphate with best price 41468-25-1

≥1 Kilogram

$241.70

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    MOQ 1 Kilogram / Kilogram
description
Product Description

  Basic Information

                                               

Product Name: Pyridoxal Phosphate;Pyridoxal 5'-Phosphate 

CAS No: 54-47-7;41468-25-1;853645-22-4

EINECS No: 200-208-3

Molecular Formular:  C8H10NO6P

Molecular Weight: 247.14

Appearance: White crystalline powder

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.

Test Report

 

 

ItemSpecificationsResults
AppearanceAlike white or light Yellow powderComplies
Content(HPLC)99.0%-101.0%99.39%
Pyridoxine (HPLC)<0.01%Complies
Loss on Drying(HPLC)10%4.46%
Heavy Metals≤20ppm10ppm
PH2.6~3.02.78
Total Plate Count≤1000CFU/gComplies
Yeast & Mold≤100CFU/gComplies
E ColiNegativeComplies
ColiformsNegativeComplies
SalmonellaNegativeComplies
Staphylococcus serousNegativeComplies
ConclusionThe results conforms with enterprise standards

 

                        Application Area

 

 

Function

PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.
In transamination, after deprotonation the quinoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex.
In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine. In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.
PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).It is also active in the condensation reaction in heme synthesis.
PLP plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines.

 

Application

1) Pyridoxal-5-Phosphate is used to treat Parkinson's disease
2) Promote the transaminase in transamination dopamine levels in the body
3) Used in the treatment of acute or chronic eczema dermatitis nettle examine pustular rash itching seborrheic eczema scaly rash drug eruption deficiency oral inflammation glossitis pregnancy reaction, asthma, etc
4) The main body of vitamin B6

 

 
Company Information

Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
 
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

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FAQ
Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.
 
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Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
 
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