≥1 Kilograms
$183.30
Product Description
Product Name: Topiramate
Synonyms:McN-4853; RWJ-17021; Topamax; 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
Molecular weight: 339.36
Molecular formula:C12H21NO8S
CAS No.: 97240-79-4
Purity:99%
Appearance:White or colourless crystalline powder with characteristic odor
Topiramate,Topiramate powder
Anticonvulsant Powder Topiramate CAS 97240-79-4 Pure Topiramate
Certification of Analysis
Items | Specifications | Results |
Appearance | White to off-white powder, Freely soluble in dichloromethane | White powder, Freely soluble in dichloromethane |
Identification | Infared Absorption | Complies |
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay | complies | |
Specific rotation | Between -28.6°and -35.0°, measured at 20° | -32.8° |
Water | not more than 0.5% | 0.12% |
residue on ignition | not more than 0.2% | 0.11% |
Heavy metals | not more than 0.001% | complies |
related compounds by HPLC(Test1) | Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% | Fructose: 0.03% Compound A: 0.04% individual impurity 0 Total impurities: 0.07% |
Particle size | 90% less than 350 microns | complies |
Limit of sulfamate and sulfate | Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% | complies |
Residual Solvent | Methylene Chloride not more than 250μg/g | not detected |
Acetone not mor than 2500μg/g | ||
Isopropanol not more than 5000μg/g | ||
Ethanenitrile not more than 400μg/g | ||
n-hexane not more than 290μg/g | ||
Ethyl Acetate not more than 2500μg/g | ||
Pyridine not more than 100μg/g | ||
Assay | Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis | 99.80% |
Conclustion | The material complies with respect to USP35 |
Function&Application
-Topiramate is used to treat epilepsy in children and adults, and it was originally used as an
anticonvulsant.
In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures
and developmental delay.
-Topiramate has been investigated for use in treating alcoholism,and obesity, especially to reduce binge
eating.
-Topiramate is also widely used to treat migraines due to the effect it has on the blood vessels in the brain
-Topiramate is also used in clinical trials to treat post traumatic stress disorder
-And recently. clinical reports indicate that Topiramate may have mood stabilizing properties.
Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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