≥1 Kilograms
$1,416.66
Product Description
Name | Rosuvastatin calcium |
Synonyms | 7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid |
Molecular Formula | 2(C22H27FN3O6S).Ca;C44H54CaF2N6O12S2 |
Molecular Weight | 1001.14 |
CAS Registry Number | 147098-20-2 |
Melting point | 122 ºC |
Rosuvastatin Calcium is the calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.
Certification of Analysis
Tests | Specifications | Results |
Appearance | A White to off-white powder | Complies |
Specific Rotation | +17°~+21° | +20° |
Identification | A. Meets the requirement B. UV: λmax=243nm C. IR: similar to Reference Substance D.X-ray: similar to Reference Substance | Complies Complies Complies Complies |
Chloride | ≤0.1% | Complies |
Sulphate | ≤0.1% | Complies |
Enantiomer | ≤0.15% | Undetected |
Calcium | 3.9%~4.3% | 4.1% |
Related substances | Diastereomer≤0.15% | 0.06% |
5-oxo-Rosucastatin≤0.15% | Undetected | |
Photo degradation 1≤0.15% | Undetected | |
Photo degradation 2≤0.15% | Undetected | |
Rosuvastatin lactone≤0.15% | Undetected | |
Rosuvastatin methyl ester≤0.15% | Undetected | |
Rosuvastatin isoamyl ester≤0.15% | Undetected | |
Any unknown impurity≤0.10% | 0.05% | |
Total impurities≤0.75% | 0.28% | |
Water | ≤3.0% | 2.1% |
Isoamyl Bromide | ≤37.5ppm | ≤37.5ppm |
Residual solvents | Ethyl ether≤300ppm Undetected | Complies |
Acetonitrile≤410ppm Undetected | Undetected | |
Isoamyl alcohol≤5000ppm Undetected | Undetected | |
DMF≤880ppm Undetected | Undetected | |
Assay | 98.5%~102.0%( caculated on the anhydrous basis) | 99.8% |
Function&Application
Rosuvastatin calcium is a HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES.
Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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