1-1000 Grams
$10.00
≥1001 Grams
$4.00
Product Description
Product Name: Polymyxin B Sulfate
Specification: 99%
Cas No: 1405-20-5
Einecs No: 215-774-7
Molecular formula: C48H84N16O17S
Molecular weight: 1301.56
Polymyxin B sulfate is similar with polymyxin E, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Escherichia coli deputy, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella dysentery.
It is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by Pseudomonas aeruginosa and other kinds of pseudomonas. It can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and Pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.
Certification of Analysis
Items | Specification | Result |
Appearance | White to almost white powder | Complies |
Identification | A. Liquid chromatographic identification test B. A reddish violet color is produced C. Test for sulfate | Complies |
Loss on drying | ≤7.0% | 3.5% |
PH(2%) | 5.0-7.0 | 6.6 |
Phenylalanine | 9.0%~12.0% | 11.0% |
Sulphated ash | ≤0.75% | 0.01% |
Specific optical rotation | -78°~-90° | -65.6° |
Sulphate | 15.5%~17.5% | 16.0% |
Heavy metal | ≤20ppm | Complies |
Assay(microbial) (on dried basis) | ≥6500iu/mg | 8063iu/mg |
Particle size | 99.0% not more than 30um by vol. 90.0% not more than 25um by vol. 75.0% not more than 20um by vol. Mean diameter not more than 8.0um. | <20
<20 |
Function&Application
Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.
Qingdao Sigma chemical Co., Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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