Rotundine powder, an analgesic drug, has been entrapped in a PIC polysaccharide granule. It was prepared in a two-step process, i.e., first granulation of a chitosan acetated solution containing Rotundine and then complexation of the polycationic component on the granular surface with a polyanionic solution of carboxymethyl glucomannan (CMGM). The granule has an average diameter of 1.38–1.53 mm and the drug content reaches 62.8%.

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